The Effect of Training on Motoneuron Survival in Amyotrophic Lateral Sclerosis: Which Motoneuron Type is Saved?

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The Effect of Training on Motoneuron Survival in Amyotrophic Lateral Sclerosis: Which Motoneuron Type is Saved?

Amyotrophic lateral sclerosis (ALS) is characterized by selective and progressive degeneration of motoneurons (MNs). Although the etiology of the disease is unknown, glutamate toxicity and reac-tive oxygen species toxicity have been strongly implicated in ALS pathophysiol-ogy, Training exercise has been proposed to provide a beneficial therapy during the early or late stages of ALS (Pinto et al...

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In amyotrophic lateral sclerosis (ALS) the large motoneurons that innervate the fast-contracting muscle fibers (F-type motoneurons) are vulnerable and degenerate in adulthood. In contrast, the small motoneurons that innervate the slow-contracting fibers (S-type motoneurons) are resistant and do not degenerate. Intrinsic hyperexcitability of F-type motoneurons during early postnatal development ...

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ژورنال

عنوان ژورنال: Frontiers in Physiology

سال: 2011

ISSN: 1664-042X

DOI: 10.3389/fphys.2011.00018